Cytohesins Are Cytoplasmic ErbB Receptor Activators
نویسندگان
چکیده
Anke Bill,1,8 Anton Schmitz,1,8 Barbara Albertoni,1 Jin-Na Song,1 Lukas C. Heukamp,2 David Walrafen,3 Franziska Thorwirth,4 Peter J. Verveer,4 Sebastian Zimmer,2 Lisa Meffert,2 Arne Schreiber,3 Sampurna Chatterjee,5 Roman K. Thomas,5,6,7 Roland T. Ullrich,5 Thorsten Lang,3 and Michael Famulok1,* 1LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany 2Institute of Pathology, Universitätsklinikum, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud Strasse 25, 53123 Bonn, Germany 3LIMES Institute, Program Unit Membrane Biology & Lipid Biochemistry, Laboratory of Membrane Biochemistry, Rheinische Friedrich-Wilhelms-Universität Bonn, Carl-Troll-Straße 31, 53115 Bonn, Germany 4Department of Systemic Cell Biology, Max-Planck Institute of Molecular Physiology, Otto-Hahn-Str. 11, 44227 Dortmund, Germany 5Max Planck Institute for Neurological Researchwith Klaus-Joachim-Zülch Laboratories of theMax Planck Society and theMedical Faculty of the University of Köln, Gleueler Str. 50, 50931 Köln, Germany 6Chemical Genomics Centre of the Max Planck Society, Otto-Hahn Str. 15, 44227 Dortmund, Germany 7Center of Integrated Oncology and Department I of Internal Medicine, University of Köln, Kerpener Straße 62, 50937 Köln, Germany 8These authors contributed equally to this work *Correspondence: [email protected] DOI 10.1016/j.cell.2010.09.011
منابع مشابه
RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decreased ErbB receptor autophosphorylation and signaling, whereas cytohesin overex...
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(Cell 143, 201–211; October 15, 2010) In Bill et al., we identified the cytohesin ARNO as an ErbB receptor activator that enhances receptor autophosphorylation in H460 and SkBr3 cells. Cell-free reconstitution with purified proteins showed that ARNO enhances EGF receptor autophosphorylation by direct interaction with the intracellular domain of the receptor (EGFR-ICD). Wewere recently notified ...
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